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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name rno-miR-365
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line rat Müller cell line rMC-1; retinas
Methods qRT-PCR, luciferase report assay, Western blot, immunofluorescence, in situ hybridization (ISH), ERG
Expression pattern up-regulated
Functional description miR-365 was found to be highly expressed in the retina and the abnormality of miR-365/Timp3 pathway is closely related to the pathology, like Müller gliosis, and the visual injury in DR.
PubMed ID 29196060
Year 2018
Title miR-365 promotes diabetic retinopathy through inhibiting Timp3 and increasing oxidative stress.
Drug-related ncRNA NO

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